Recruiting and retaining medical patients in trials of complex interventions: practical experience of challenges and solutions in three multi-centre trials
نویسندگان
چکیده
Objectives 1. To consider the challenges of recruiting and retaining medical patients in trials of complex interventions, that include ‘psychological’ components. 2. To discuss practical solutions to these challenges that ensure trials recruit to target and maximise outcome data collection. Examples are taken from three trials of complex interventions: SMaRT Oncology-2, SMaRT Oncology-3 and SMaRT Neurology-1.
منابع مشابه
مرور ملاحظات اخلاقی و نقد میزان خطر قابل قبول در کارآزمایی بالینی بر داوطلب سالم
Healthy volunteers are the first group who take part in experimental studies on the efficacy of new drugs. Parallel with expanding the boundaries of medical science, medical research has shown rapid growth which has caused new and critical ethical challenges in medical research.A clinical trial is one of the essential methods in clinical research and a very challenging method from the ethical v...
متن کاملDesigning and analysing pragmatic clinical trials of complex interventions in mental health: challenges and solutions
Objectives Designing and analysing pragmatic clinical trials involving complex interventions is becoming increasingly complex, particularly in the field of mental health. This paper will describe a variety of challenges encountered during the design of a complex intervention mental health trial and the decisions made on how to overcome these challenges. The objectives are to share knowledge gai...
متن کاملThe Effectiveness of Psychological Interventions on Reducing the Symptoms of Post-Traumatic Stress Disorder in Military Personnel: A Systematic Review
Background and Aim: Considering the nature of post-traumatic stress disorder (PTSD) in the military profession, challenges in the effectiveness of psychological interventions on the symptoms of the disorder and sustainable recovery have been reported among the military population. The present research aims to identify effective psychological interventions for PTSD symptoms and compare their eff...
متن کاملEffectiveness of Support Resources for Patients with Type 2 Diabetes: A Systematic Review of Clinical Trials in Iran
Introduction and Objectives: Type 2 diabetes is a common metabolic disorder worldwide. Health policymakers face challenges in the management of this chronic disease. According to previous studies, due to the complex nature of diabetes, the use of support resources can be effective in improving disease management. The current study aimed to identify the sources of support for patients with type ...
متن کاملCell Therapy in Cardiovascular Disease
Recently, cell therapy has sparked a revolution in ischemic heart disease that will in the future help clinicians to cure patients. Earlier investigations in animal models and clinical trials have suggested that positive paracrine effects such as neoangiogenesis and anti-apoptotic can improve myocardial function. In this regard the Royan cell therapy center designed a few trials in collaborat...
متن کامل